Cross-reactive idiotypes in immunoglobulin A-deficient sera.
نویسندگان
چکیده
منابع مشابه
Cross-reactive idiotypes in immunoglobulin A-deficient sera.
Mice of inbred strains immunized with simple antigens can produce antibodies that share similar V regions, which result in serologic similarities called cross-reactive idiotypes (CRI). In this study, we considered the possibility that IgA-deficient humans, who are continuously immunized via the intestinal tract by dietary protein, might also produce antibodies sharing CRI. For this, anti-casein...
متن کامل1386 Immunoglobulin Diversity and Idiotypes
Two of the intriguing questions in immunology, which in many instances may be related, are the mechanisms by which the vast array of immunoglobulin diversity is generated and the structure of antigenic determinants associated with these molecules. It is now clear that several processes contribute to immunoglobulin diversity. First, there are an apparently large number of both light (L) ~ and he...
متن کاملInheritance of immunoglobulin M rheumatoid-factor idiotypes.
The idiotypic determinants on IgM rheumatoid factor (RF) from a single family have been analyzed. Rabbit Fab'2 antiidiotypic antibody was prepared against purified IgM-RF from a patient with rheumatoid arthritis. As measured by radioimmunoassay, the antiidiotype reacted with at least 90% of the patient's RF, but not with non-RF immunoglobulins from the same serum, nor with 10 of 11 polyclonal a...
متن کاملDifferential Expression of Rheumatoid Factor-Associated Cross-Reactive Idiotypes in Iranian Seropositive and Seronegative Patients with Rheumatoid Arthritis
High levels of rheumatoid factors (RF) are detectable in serum of the majority of patients with rheumatoid arthritis (RA), but 5-10% of patients remain seronegative (SN). Despite clinical and genetic similarities between these two subsets of RA, it has been proposed that they may be regarded as distinct clinical entities. Methods: In the present study a panel of monoclonal antibodies (mAb) rec...
متن کاملChanges in immunoglobulin control sera.
References 1. Khayam-Bashi, H., and Sims, C., Effect of sodium aside on the quantitation of chemical constituents of serum. Am. ,J. Clin. Pat hol. 69, 405 (1978). 2. Khayam-Bashi, H., Sims, C., and Parekh, A. C., Interference of sodium azide with the quantitation of serum cholesterol: A comparative study. Clin. Chim. Acta 66, 69 (1976). 3. Queen, A., and Frings, C. S., Effect of sodium azide on...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 1985
ISSN: 0021-9738
DOI: 10.1172/jci111882